☰ Contents · Biology (Cytology and genetics)

Lipids, amino acids and proteins

Lessons 23–24 · 2 lessons · A. Zikiryayev, A. To‘xtayev, I. Azimov, N. Sonin. Biology. Basics of Cytology and Genetics, Grade 9, revised and expanded 5th edition. “Yangiyul Poligraph Service”, Tashkent, 2019
24

Proteins. Amino acids

Textbook: pp. 63–65
GoalExplain the elemental composition of proteins, the structure of amino acids and the formation of the peptide bond.
New words
amino acid · aminokislotapeptide bond · peptid bog‘polypeptide · polipeptidessential amino acid · almashtirib bo‘lmaydigan aminokislota
Explanation

Proteins stand first among the organic substances of the cell in amount and importance; they contain about 50–54 % carbon, 21–23 % oxygen, 6.5–7.3 % hydrogen, 16 % nitrogen and a little sulfur. The monomer of a protein is the amino acid: general formula H₂N–CH(R)–COOH, that is an amino group (–NH₂), a carboxyl group (–COOH) and a radical (R); amino acids differ only in the radical. Proteins contain 20 kinds of amino acids. When two amino acids join, a molecule of water is released from the –COOH group of one and the –NH₂ group of the other, and they are linked by a peptide bond (–CO–NH–); two form a dipeptide, many a polypeptide, and a chain of n amino acids has n − 1 peptide bonds. Plants and many microorganisms synthesise all amino acids, while humans get about nine (the essential ones) only from food; children may need a few more. Today many of them are produced industrially with microorganisms and biotechnology.

Worked examples
Glycine is the simplest amino acid (R = H). If glycine and alanine join to form a dipeptide, 1 peptide bond and 1 molecule of water form.
A polypeptide of 120 amino acids in one chain has 120 − 1 = 119 peptide bonds.
Class activity

“Peptide chain”. Students join hands to form a chain: each student is an amino acid, each handhold a peptide bond. How many bonds are there with 8 students? Change the number of students to find the rule (n − 1).

Practice
1
Name the three components of an amino acid.
2
One alpha chain of haemoglobin consists of 141 amino acids. How many peptide bonds are in this chain?
3
Why must a person get protein or essential amino acids in food?
4
If 99 peptide bonds form in protein synthesis, how many water molecules are released and how many amino acids does the chain contain?