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Biotechnology and achievements in Uzbekistan

Lessons 34–35 · 2 lessons · A. G‘afurov, A. Abdukarimov, J. Tolipova, O. Ishankulov, M. Umaraliyeva, I. Abdurahmonova. Biology, Grade 10, 1st edition. “Sharq” publishing and printing joint-stock company, Tashkent, 2017
34

Biotechnology based on genetic and cell engineering

Textbook: pp. 143–144
GoalExplain the concept of biotechnology, traditional and modern biotechnology, its directions and achievements such as gene therapy and stem cells.
New words
biotechnology · biotexnologiyagene therapy · gen terapiyasistem cell · asos hujayrabioreactor · bioreaktor
Explanation

Biotechnology is the technology of producing needed products with living organisms, their cells or biological molecules. Traditional biotechnology includes long-known processes: yoghurt and cheese from milk, bread from dough, vinegar and wine from fruit and grapes (microorganisms take part in these), and also the creation of breeds of animals and varieties of plants. Modern biotechnology relies on genetic and cell engineering: microorganisms are grown in bioreactors and give insulin, growth hormone (somatotropin), interferon, the hepatitis B vaccine, enzymes, vitamins and antibiotics; diagnostic test systems and biodegradable plastics are made. Environmental biotechnology uses microorganisms that break down pollutants in soil and water. In gene therapy a healthy (functional) gene is introduced into the cells of a sick organism; methods that treat some hereditary diseases this way have been developed and are in use, and research continues. Stem cells are unspecialised cells able to become different tissues (J. Thomson, 1998, human embryonic stem cells); ways of growing tissues and organs from them are being studied. Since 2012 the CRISPR/Cas9 method has allowed precise editing of the genome; there are serious ethical limits on changing human heredity.

Worked examples
In making yoghurt, lactic acid bacteria turn lactose into lactic acid – traditional biotechnology. In a bioreactor, an insulin gene put into E. coli makes insulin protein – modern biotechnology.
In an industrial bioreactor the number of bacteria doubles every 20 minutes. In 1 hour it grows 2 · 2 · 2 = 8 times; so large amounts of product can be obtained quickly.
Class activity

“Which biotechnology?”: pictures and names (yoghurt, insulin, vaccine, wine, vinegar) are sorted into traditional and modern columns.

Practice
1
Give two examples each of traditional and modern biotechnology.
2
What is gene therapy?
3
The number of bacteria doubles every 20 minutes. How many does one cell give in 2 hours 20 minutes? (Number only.)
4
Why are stem cells promising for medicine?